Phulara, N.R., Rege, A., Bieberich, C.J., and Seneviratne, H.K. (2024). MALDI mass spectrometry imaging reveals region-specific lipid alterations in the mouse brain in response to efavirenz treatment. ACS Pharmacology and Translational Science. DOI: 10.1021/acsptsci.4c00228. Manuscript accepted.
Khojasteh, S.C., Argikar, U.A., Chatzopoulou, M., Cheruzel, L., Cho, S., Dhaware D., Johnson, K.M., Kalgutkar, A.S., Liu, J., Ma, B., Maw, H., Rowley, J.A., Seneviratne, H.K., and Wang, S., (2024). Biotransformation research advances – 2023 year in review. Drug Metabolism Reviews. Manuscript in review (All authors contributed equally). Manuscript accepted.
Wang, S., Argikar, U.A., Chatzopoulou, M., Cho, S., Crouch, R., Dhaware D., Gu, T., Heck, C.J.S., Johnson, K.M., Kalgutkar, A.S., Liu, J., Ma, B., Miller, G.P., Rowley, J.A., Seneviratne, H.K., Zhang, D., and Khojasteh, S.C., (2024). Bioactivation and reactivity advances – 2023 year in review. Drug Metabolism Reviews. Manuscript in review (All authors contributed equally). Manuscript accepted.
Phulara, N.R. and Seneviratne, H.K. (2024). Mass spectrometry imaging-based multi-omics approaches to understand drug metabolism and disposition. Journal of Mass Spectrometry. Manuscript accepted.
Phulara, N.R., Ishida, C., Espenshade, P., and Seneviratne, H.K. (2024). Cytosolic 5’-nucleotidase III and nucleoside triphosphate diphosphohydrolase 1 dephosphorylate the pharmacologically active metabolites of gemcitabine and emtricitabine. Drug Metabolism and Disposition. 52: 288-295. DOI: https://doi.org/10.1124/dmd.123.001508
Wang, S., Argikar, U.A., Cheruzel, L., Cho, S., Crouch, R., Dhaware D., Heck, C.J.S., Johnson, K.M., Kalgutkar, A.S., King, L., Liu, J., Ma, B., Maw, H., Miller, G.P., Seneviratne, H.K., Takahashi, R.H., Wei, C., and Khojasteh, S.C., (2023). Bioactivation and reactivity advances – 2022 year in review. Drug Metabolism Reviews, 55:4, 267-300. (All authors contributed equally) DOI: https://doi.org/10.1080/03602532.2023.2244193
Khojasteh, S.C., Argikar, U.A., Cheruzel, L., Cho, S., Crouch, R., Dhaware D., Heck, C.J.S., Johnson, K.M., Kalgutkar, A.S., King, L., Liu, J., Ma, B., Maw, H., Miller, G.P., Seneviratne, H.K., Takahashi, R.H., Wang, S., Wei, C., and Jackson, K.D. (2023). Biotransformation novel advances – 2022 year in review. Drug Metabolism Reviews, 54:3, 207-245. (All authors contributed equally) DOI: https://doi.org/10.1080/03602532.2022.2097253
Washington-Hughes, C.L., Roy, S., Seneviratne, H.K., Karuppagounder, S.S., Morel, Y., Jones, J.W., Zak, A., Xiao, T., Boronina, T.N., Cole, R.N., Bumpus, N.N., Chang, C.J., Dawson, T.M., and Lutsenko, S. (2023). ATP7B-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain. PLOS Genetics, 19:1, e1010558. DOI: https://doi.org/10.1371/journal.pgen.1010558
Seneviratne, H.K., (2023). Nucleoside triphosphate diphosphohydrolase 1 exhibits enzymatic activity toward tenofovir diphosphate. Drug Metabolism and Disposition, 51:3, 385-391. DOI: https://doi.org/10.1124/dmd.122.000855
Wheeler, A.M.., Eberhard, C.D., Mosher, E.P., Yuan, Y., Wilkins, H.N., Seneviratne, H.K., Orsburn, B.C., and Bumpus, N.N., (2023). Achieving a deeper understanding of drug metabolism and responses using single cell technologies. Drug Metabolism and Disposition, 51:3, 350-359. DOI: https://doi.org/10.1124/dmd.122.001043
Jackson, K.D., Argikar, U.A., Cho, S., Crouch, R., Driscoll, J.P., Heck, C.J.S., King, L., Maw, H., Miller, G.P., Seneviratne, H.K., Wang, S., Wei, C., Zhang, D., and Khojasteh, S.C., (2022). Bioactivation and reactivity advances – 2021 year in review. Drug Metabolism Reviews, 54:3, 246-281. (All authors contributed equally) DOI: https://doi.org/10.1080/03602532.2022.2097254
Khojasteh, S.C., Argikar, U.A., Cho, S., Crouch, R., Heck, C.J.S., Johnson, K.M., Kalgutkar, A.S., King, L., Maw, H., Seneviratne, H.K., Wang, S., Wei, C., Zhang, D., and Jackson, K.D. (2022). Biotransformation novel advances – 2021 year in review. Drug Metabolism Reviews, 54:3, 207-245. (All authors contributed equally) DOI: https://doi.org/10.1080/03602532.2022.2097253
Prior to 2022
Seneviratne, H.K., Hamlin, A.N., Li, S., Grinsztejn, B., Dawood, H., Liu, A.Y., Kuo, I., Hosseinipour, M.C., Panchia, R., Cottle, L., Chau, G., Adeyeye, A., Rinehart, A.R., McCauley, M., Eron, J.J., Cohen, M.S., Landovitz, R.J., Hendrix, C.W., and Bumpus, N.N. (2021). Identification of novel UGT1A1 variants including UGT1A1 454C>A through the genotyping of healthy participants of the HPTN 077 study. ACS Pharmacology and Translational Science, 4: 226-239. DOI: https://doi.org/10.1021/acsptsci.0c00181
Seneviratne, H.K†., Tillotson, J†., Lade, J.M., Bekker, L.G., Li, S., Pathak, S., Justman, J., Mgodi, N., Swaminathan, S., Sista, N., Farrior, J., Richardson, P., Hendrix, C.W., and Bumpus, N.N. (2021). Metabolism of long acting rilpivirine following intramuscular injection: HIV Prevention Trials Network Study 076 (HPTN 076). AIDS Research and Human Retroviruses, 37: 173-183. DOI: https://doi.org/10.1089/AID.2020.0155
† – These authors contributed equally to this work.
Seneviratne, H.K., Hamlin, A.N., Heck, C.J.S., and Bumpus, N.N. (2020). Spatial distribution profiles of emtricitabine, tenofovir, efavirenz, and rilpivirine in murine tissues following in vivo dosing correlate with their safety profiles in humans. ACS Pharmacology and Translational Science, 3, 4: 655-665. DOI: https://doi.org/10.1021/acsptsci.0c00015
Heck, C.J.S., Seneviratne, H.K., and Bumpus, N.N. (2020). Twelfth-position deuteration of nevirapine reduces 12-hydroxy-nevirapine formation and nevirapine-induced hepatocyte death. Journal of Medicinal Chemistry: Special Issue on Drug Metabolism and Toxicology, 63: 6561-6574. DOI: https://doi.org/10.1021/acs.jmedchem.9b01990
Zhang, D., Hop, C., Patilea-Vrana, G., Gampa, G., Seneviratne, H.K., Unadkat, J.D., Kenny, J.R., Nagapudi, K., Di, L., Zhou, L., Zak, M., Wright, M.R., Bumpus, N.N., Zang, R., Liu, X., Lai, Y., and Khojasteh, S.C. (2019). Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities. Drug Metabolism and Disposition, 47: 1122-1135 (All authors contributed equally and are listed alphabetically by first name except for the first and last author). DOI: https://doi.org/10.1124/dmd.119.086744
Seneviratne, H.K., Hendrix, C.W., Fuchs, E.J., and Bumpus, N.N. (2018). MALDI mass spectrometry imaging reveals heterogeneous distribution of tenofovir and tenofovir diphosphate in colorectal tissue of subjects receiving a tenofovir-containing enema. Journal of Pharmacology and Experimental Therapeutics, 367: 40-48. DOI: https://doi.org/10.1124/jpet.118.250357
Seneviratne, H.K., (2017). Towards understanding dirigent protein function, ProQuest Dissertations Publishing, 10269677. DAI-B 79/02(E), Dissertation Abstracts International
Seneviratne, H.K., Dalisay, D.S., Kim, K.-W., Moinuddin, S.G.A., Yang, H., Davin, L.B., and Lewis, N.G. (2015). Non-host disease resistance response in pea (Pisum sativum) pods: Biochemical function of DRR-206 and phytoalexin pathway localization. Phytochemistry, 113: 140-148. DOI: https://doi.org/10.1016/j.phytochem.2014.10.013