Research Interests

Drug Disposition and Response

The Seneviratne laboratory employs innovative mass spectrometry imaging-based multi-omics strategies and biochemical approaches to understand the mechanistic differences in drug responses and disposition. Additionally, we focus on deciphering abnormal regulation of lipid metabolism in brain cells in aging and neurodegenerative diseases.

Research Areas

Analytical Chemistry, Biochemistry, Pharmacology, Toxicology, and Imaging

Research Projects

Project 1: Nucleotidase-mediated drug dephosphorylation

Project 2: Abnormal regulation of lipid metabolism in brain cells during aging and neurodegeneration

Project 3: Mechanistic differences in drug-induced neurotoxicity

The overarching goal of our work is to integrate mechanistic understanding of drug response, disposition, interindividual variability, and 3-dimensional distribution of drugs in cells and tissues to enable the personalization of medicine.

We truly believe that our unique interdisciplinary approach will help develop safe, effective medications and doses that will be tailored to individuals.